The game is set some months after the events of the film.

Peter Parker and Gwen Stacy sneak into the restricted areas of Oscorp after hours, where Gwen reveals her suspicions that they may be continuing Curt Connors' cross-species experiments. In the process, they are caught by Alistair Smythe, the new director, who explains that some scientists were indeed secretly continuing Connors' cross-species experiments by injecting animals with human DNA; the cross-species carry a powerful virus and are currently being shipped to a bio-lab for disposal. At that moment, the cross-species all react to Peter's presence and escape, infecting all of the scientists, including Smythe and Gwen, in the process. Alistair unleashes his security robots, which are programmed to defend them from cross-species. However, they end up attacking Peter, as he technically is a cross-species too. Peter quickly dons his Spider-Man suit and gets the infected to quarantine, fighting off the robots in the process, but is unable to stop the cross-species from escaping into the city.

Spider-Man tries to fight off the cross-species in the city, but they all escape, and a giant security robot attacks him too, causing great damage to the city. Spider-Man goes to the Beloit Psychiatric Hospital, where Dr. Connors has been incarcerated since the Lizard's rampage, and informs him of the incident. Connors agrees to escape from the institution and help Spider-Man develop a cure for the outbreak, but only if he is returned to the asylum when the crisis is resolved. After breaking out Connors, Spider-Man returns to his Aunt May's friend Stan's apartment (which he has been house sitting) with Connors, where they immediately set up a laboratory to begin development of the antidote, which soon becomes a race against time when it is discovered that Smythe is developing his own "cure" which involves nanobots destroying the host from the inside out. Along the way, Spider-Man hacks into police and Oscorp transmissions with his Spider-Tracers and forms an alliance with Whitney Chang, an investigative reporter who believes Oscorp's facelift operation is a scam.




Minimum System Requirements

* OS: Windows 7 or (Windows® XP (with Service Pack 3) and (DirectX® 9.0c) or (Windows Vista® with Service Pack 2)

* CPU: Intel Core® 2 Duo 2.6 GHz or AMD Athlon 64 X2 3800+

* RAM: 3 GB

* HDD: 8.1 GB of uncompressed hard disk space (Plus 500 MB for swap file)

* GPU RAM: 512 MB 3D hardware accelerator card required – 100% DirectX® 9.0c with Shader Model 3 support.

* Graphics: NVidia GeForce 8800 GT / AMD Radeon HD 4650

* Sound Card: DirectX 9.0ΓÇôcompliant sound card

* NET: Broadband recommended

Recommended System Requirements

* OS: Windows 7 SP1 or (Windows® XP) and (DirectX® 9.0c) or (Windows Vista® with Service Pack 2) x64

* CPU: Intel Core® 2 Quad 2.4 Ghz or AMD Athlon II X4 2.6 Ghz

* RAM: 4 GB

* HDD: 8.1 GB of uncompressed hard disk space (Plus 500 MB for swap file)

* Graphics: Nvidia GeForce 285 GTX / AMD Radeon HD 4830

* Sound Card: DirectX 9.0ΓÇôcompliant sound card

* NET: Broadband recommended

nothing cut from the game
have DLC Package : Lizard Rampage Pack , Rhino Challenge , Oscorp Search and Destroy Pack , Stan Lee Adventure Pack

Just install and start with administrator right

the game up on 28.09.2012 . 
integrated also Update 1 and DLC Package : Lizard Rampage Pack , Rhino Challenge , Oscorp Search and Destroy Pack , Stan Lee Adventure Pack .

Tested on win7 x64 sp1 proffesional and works 100%